مقایسه اثر سمیت سلولی نانوذرات کیتوزان- دوسه تاکسل و داروی آزاد دوسه تاکسل بر روی سلول های سرطانی سینه MDA-MB-231

Background and objective: Resulting in the accumulation of somatic mutations in cancer cells caused. Breast cancer is the most commonly diagnosed cancer among women worldwide. The use of nanoscale drug delivery systems is important for effective treatment. The main aim of this study was to determine effects of chitosan conjugated to docetaxel nanoparticles in treatment of breast cancer. Methods: The self-assembled nanoparticle were prepared though conjugation of docetaxel , using succinic anhydride as a linker. Conjugation was confirmed by nuclear magnetic resonance spectroscopy (1H-NMR) studies. Evaluation of the in vitro cytotoxicity of the nanoparticles by MTT assay. Results: The results indicated that prepared nanoparticles have spherical shape with narrow size distribution around 150 nm with positive zeta potential. Acording to in vitro studies, we observed increased cell death in treat by nanoparticles Conclusion: Our finding show that docetaxel-chitosan nanoparticles can be suggested as an effective anticancer combination for breast cancer treatment.